Indever 40mg Tablet

Uses of Indever 40mg Tablet

• Hypertension
• Angina pectoris
• Migraine prevention
• Hypertrophic subaortic stenosis
• Heart attack
• Pheochromocytoma
• Arrhythmias

How does Indever 40mg Tablet work?

Indever 40mg Tablet works by reducing the blood pressure by blocking the beta2 receptors present on the heart which are responsible for the increased blood pressure. It also relaxes the blood vessels which enhance proper blood flow in the body.

Side Effects of Indever 40mg Tablet

• Dizziness and lightheadedness
• Diarrhea
• Difficulty in breathing
• Nausea or vomiting
• Weight gain
• Constipation
• Irregular heartbeat
• Unusual tiredness and weakness
• Chest Pain
• Hypotension
• Cardiogenic Shock
• Light Headedness
• Confusion
• Dizziness
• Insomnia
• Fatigue
• Lethargy
• Cold Extremities
• Vertigo
• Syncope
• Hallucination
• Rash
• Alopecia
• Pruritus
• Urticaria
• Contact Dermatitis
• Nausea
• Vomiting
• Stomach Discomfort
• Anorexia
• Impotence
• Thrombocytopenia
• Weakness
• Wheezing
• Bronchospasm
• Pharyngitis

Quick Suggestions:

• Take Indever 40mg Tablet in the exact dose and duration as prescribed by your doctor. Do not exceed the recommended dose.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. If you become pregnant while taking this medication, stop taking it immediately and consult your doctor.
• Discuss your complete medical history and inform your doctor about all other medicines you are taking.
• Maintain a healthy weight with a body mass index (BMI) of 19.5-24.9.
• Engage in regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. This can help lower your blood pressure by approximately 5 mmHg.
• Opt for a diet rich in whole grains, fruits, vegetables, and low-fat dairy products.
• Limit your daily sodium chloride (table salt) intake to 2300 mg or less, ideally less than 1500 mg for most adults.
• If you consume alcohol, limit it to one serving for women and two servings for men.
• Quit smoking to reduce the risk of heart disease.
• Manage chronic stress and practice mindfulness techniques. Spend time with loved ones and engage in activities you enjoy.
• Monitor your blood pressure regularly and contact your doctor if there are significant fluctuations.
• Include heart-healthy foods and drinks containing omega-3 fatty acids in your diet. Use low-fat cooking oils such as olive oil, soybean oil, canola oil, and coconut oil to help lower your blood pressure.
• Be aware that this medication may make it harder to control your blood sugar. Check your blood sugar regularly and share the results with your doctor.
• Seek immediate medical attention if you experience symptoms such as shortness of breath with a cough worsened by exercise, swollen ankles or legs, chest pain, or an irregular heartbeat, as these may indicate heart problems.
• Some individuals may experience tiredness, fatigue, dizziness, or nausea/vomiting with the use of this medicine. Inform your doctor if these side effects bother you or do not go away.
• If you feel dizzy or sleepy after taking Indever 40mg Tablet, avoid driving, operating heavy machinery, or performing tasks that require mental alertness.
• Along with taking Indever 40mg Tablet, make necessary lifestyle changes such as following a low-fat, low-salt diet, maintaining a healthy weight, exercising for 30 minutes daily, quitting smoking, and limiting alcohol consumption.

Indication

Indever 40mg Tablet is indicated for the treatment of various conditions and can be used to:

• Treat hypertension (high blood pressure)
• Treat angina pectoris (chest pain)
• Treat arrhythmia (irregular heart rhythm)
• Prevent heart attacks
• Prevent migraines (severe headaches on one side of the head)
• Reduce tremors (shakiness) and anxiety
• Reduce gut bleeding caused by high blood pressure in the liver

Additionally, Indever 40mg Tablet can be used to alleviate signs and symptoms associated with certain conditions such as:

• The overactive thyroid gland, which may manifest as palpitations, nervousness, tremors, fixed stare, severe muscle weakness, and excessive sweating
• Phaeochromocytoma, a condition characterized by high blood pressure and a fast heart rate caused by a tumor in the adrenal glands
• Hypertrophic Subaortic Stenosis, a condition characterized by the thickening of the heart muscles, can cause strain on the heart during the pumping of blood

Pharmacology

Propranolol Hydrochloride is a drug that blocks B-adrenergic receptors and is commonly used to treat hypertension and angina pectoris. Propranolol antagonizes catecholamines at B-adrenergic receptors, preventing the heart from contracting too quickly or too forcefully and reducing the heart's oxygen consumption.

Dosage & Administration of Indever 40mg Tablet

The recommended dosages for Indever 40mg Tablet in adults and children are as follows:

Adult Dose:

1. Hypertension:

• Start with 80 mg twice daily, then gradually increase to 160-320 mg twice daily at weekly intervals.
• Maintenance dose: 160-320 mg daily.

1. Angina Pectoris:

• Initial dose: 40 mg 2-3 times daily.
• Maintenance dose: 120-240 mg daily.

1. Thyrotoxicosis:

• Initial dose: 10-40 mg, 3-4 times daily.
• Maintenance dose: 80-160 mg daily.

1. Myocardial Infarction:

• Initial dose: 40 mg 4 times daily for 2-3 days, then 80 mg twice daily.
• Alternative regimen: 180-240 mg daily in divided doses.
• Administer within 5-21 days of myocardial infarction.

1. Cardiac Arrhythmias:

• Daily dose: 30-160 mg in divided doses.

1. Prophylaxis of Migraine:

• Initial dose (conventional tab or oral solution): 40 mg twice or three times daily.
• The maintenance dose (conventional tab or oral solution): 120-240 mg daily.
• Initial dose (extended-release capsule): 80 mg once daily, may increase to 160 mg once daily.
• Maximum dose: 240 mg/day.

1. Portal Hypertension:

• Initial dose (conventional tab or oral solution): 40 mg twice daily, increased at weekly intervals up to 160 mg twice daily.
• Initial dose (extended-release capsule): 80 mg once daily, may increase to 160 mg once daily.
• Maximum dose: 320 mg once daily.

1. Hypertrophic Cardiomyopathy:

• Daily dose (conventional tab or oral solution): 10-40 mg, 3-4 times daily.

1. Hyperthyroidism:

• Daily dose (conventional tab or oral solution): 10-40 mg, 3-4 times daily.
• Initial dose (extended-release capsule): 80 mg once daily, may increase to 160 mg once daily.
• Maximum dose: 240 mg/day.

1. Anxiety:

• Daily dose (conventional tab or oral solution): 10-40 mg twice or three times daily.
• Initial dose (extended-release capsule): 80 mg once daily.
• Maximum dose: 160 mg once daily.

1. Essential Tremor:

• Initial dose (conventional tab or oral solution): 40 mg twice or three times daily.
• The maintenance dose (conventional tab or oral solution): 120-240 mg daily.
• Initial dose (extended-release capsule): 80 mg once daily, may increase to 160 mg once daily.
• Maximum dose: 240 mg/day.

Note: Dosages may vary depending on individual patient factors and should be determined by a healthcare professional.

Child Dose:

1. Hypertension:

• Initial dose (conventional tab): 1 mg/kg/day in 2 divided doses.
• Usual range: 2-4 mg/kg/day in 2 divided doses.
• Maximum dose: 4 mg/kg/day in 2 or 3 divided doses.

1. Phaeochromocytoma:

• Daily dose (conventional tab or oral solution): 0.25-0.5 mg/kg 3-4 times daily.

1. Cardiac Arrhythmias:

• Daily dose (conventional tab or oral solution): 0.25-0.5 mg/kg 3-4 times daily.

Administration: 

Indever 40mg Tablet is taken orally with or without food. It should be swallowed whole with a glass of water. It is not recommended to crush, chew, or break the tablet.

Interaction

Drug-Drug Interactions:

• Combining Indever 40mg Tablet with other beta-blockers can cause a dangerous drop in heart rate.
• Avoid using Indever 40mg Tablet with other blood pressure medications, asthma medications (such as theophylline), or certain painkillers.
• Inform your doctor if you are taking any of these medications before starting Indever 40mg Tablet.
• Alpha-blockers (prazosin, terazosin) used together with beta-blockers can increase the risk of orthostasis (low blood pressure when standing).
• Cimetidine can increase the concentration and effects of Indever 40mg Tablet.
• Clonidine withdrawal or concurrent use with beta-blockers may cause a hypertensive crisis.
• Epinephrine (including local anesthetics containing epinephrine) can cause hypertension when used with Indever 40mg Tablet.
• Several other medications, such as digoxin, flecainide, fluoxetine, glucagon, haloperidol, NSAIDs, salicylates, sulfonylureas, verapamil, and diltiazem, can interact with Indever 40mg Tablet. Consult your doctor for specific information on these interactions.

Interaction with Diseases:

• Use Indever 40mg Tablet with caution in compensated heart failure, coronary artery disease (CAD), peripheral vascular disease (PVD), and diabetes.
• It can mask signs of thyrotoxicosis and may cause fetal harm if used during pregnancy.
• Caution is advised in patients with hepatic dysfunction, and dosage adjustments may be required.
• Anesthetic agents that decrease myocardial function should be used with care.
• Indever 40mg Tablet should be used with caution or avoided in people with diabetes, thyroid disease, asthma, cardiogenic shock, heart valve problems (stenosis), low blood pressure (hypotension), coronary heart disease, liver disease, or heart failure.

Interaction with Food:

• Avoid natural licorice, as it can cause sodium and water retention and increase potassium loss.
• Protein-rich foods may increase the bioavailability of Indever 40mg Tablet.
• Changes in diet from high carbohydrate/low protein to low carbohydrate/high protein may affect the oral clearance of the medication.
• Grapefruit and protein-enriched foods can interact severely with Indever 40mg Tablet.
• Maintain a gap of at least 2 hours between taking Indever 40mg Tablet and ayurvedic, homeopathy, unani, herbal supplements, or other over-the-counter items to avoid reducing its effectiveness.

Contraindications

Patients who have a known hypersensitivity to any of the ingredients should avoid using this product.

Pregnancy & Lactation

Indever 40mg Tablet contains propranolol, which is classified as Pregnancy Category C. This means that it should be used with caution in pregnant women and only if the potential benefits outweigh the potential risks to the fetus.

It is important for pregnant women to consult their healthcare provider before taking Indever 40mg Tablet or any other medication. The healthcare provider will consider the individual circumstances and weigh the potential risks and benefits before making a recommendation.

Propranolol is excreted in human milk, so caution is also advised when administering it to nursing mothers. It is important to discuss with a healthcare provider the potential risks and benefits of taking Indever 40mg Tablet while breastfeeding. The healthcare provider can provide guidance on whether to continue breastfeeding or consider alternative treatment options.

It is crucial for pregnant women or nursing mothers to have a thorough discussion with their healthcare provider to make an informed decision about the use of Indever 40mg Tablet, taking into account their specific situation and medical history.

Precautions & Warnings

Indever 40mg Tablet should not be used under the following conditions:

• Cardiogenic shock: It should not be used in patients with cardiogenic shock, which is a condition where the heart is unable to pump sufficient blood to meet the body's needs.
• Heart failure: It should not be used in patients with heart failure, a condition where the heart is unable to pump blood effectively.
• Very slow heartbeat: If you have a very slow heartbeat (bradycardia), the use of Indever 40mg Tablet should be avoided.
• Asthma: Individuals with asthma should not use Indever 40mg Tablet.
• Serious heart conditions: It should not be used in patients with serious heart conditions such as sick sinus syndrome or any heart blockage.
• Weight: Children weighing less than 4.5 pounds should not be given Indever 40mg Tablet. It should also not be given to children below 12 years of age.

Before taking Indever 40mg Tablet, it is important to inform the doctor about any existing medical conditions, including:

• Muscle disorders: If you have muscle disorders like myasthenia gravis or rhabdomyolysis, it is important to inform the doctor before taking Indever 40mg Tablet.
• Breathing problems: Conditions such as chronic obstructive pulmonary disease (COPD), bronchitis, or emphysema should be communicated to the doctor.
• Low blood sugar level: If you have low blood sugar levels (hypoglycemia), it is important to inform the doctor.
• Low blood pressure: Individuals with low blood pressure (hypotension) should inform the doctor.
• Depression: Inform the doctor if you have depression.
• Previous heart failure: If you have had heart failure in the past, it is important to inform the doctor.
• Liver/kidney disease: If you have liver or kidney disease, it should be communicated to the doctor.
• Thyroid hormone disorder: Inform the doctor if you have a thyroid hormone disorder.
• Adrenal gland cancer: If you have adrenal gland cancer, it is important to inform the doctor.
• Circulation problems: Conditions like Raynaud's syndrome, which affects circulation, should be communicated to the doctor.

It is advisable not to discontinue the use of Indever 40mg Tablet before undergoing any surgery. The medication may mask symptoms of diabetes, so it is important to inform the doctor if you have type 1 or type 2 diabetes. Indever 40mg Tablet may worsen symptoms of congestive heart failure and bradycardia (slow heart rate of less than 60), so close monitoring is necessary. If Indever 40mg Tablet is taken with anticoagulants like warfarin, regular monitoring of prothrombin time is recommended.

Storage Conditions

Store Indever 40mg Tablet in a cool and dry place, protected from direct sunlight, moisture, and heat. Keep it away from children and pets.